The 2019 HSR&D/QUERI National Meeting was held in Washington, DC, from October 29-31, at the Washington Hilton. The 2019 conference theme was "Innovation to Impact: Research to Advance VA's Learning Healthcare Community." The meeting was attended by HSR&D/QUERI stakeholders, including researchers, clinicians, policymakers, and Veterans. The meeting was co-hosted by two HSR&D Centers of Innovation: the Center for Innovations in Quality, Effectiveness, and Safety (IQuESt), in Houston, TX, and the Pain Research, Informatics, Multimorbidities, and Education (PRIME) Center, in West Haven, CT.