A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing Ulcers - Case Series.

Singh S, Aggarwal AK, Gudisa R, Batra P, Rathi NK, Madan V, Thakur V, Sharma H, Kumar R, Khare S, Singhal L, Chaudhry R, Arora N, Singh H, Kaur J, Sharma A, Dakhale GN, Sharma V, Gautam V. A Novel Potential Treatment for Diabetic Foot Ulcers and Non-Healing Ulcers - Case Series. Infectious disorders drug targets. 2024 Jan 1; 24(4):29-39.

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Abstract:

< p > Introduction: Appropriate care and treatment of a wound is the need of the hour whether it is an infected or a non-infected wound. If wound healing is delayed for some reason, it leads to serious complications and further increases the hospital stay and cost of treatment. Herein, we describe a novel antimicrobial wound dressing formulation (VG111), with an objective to generate the preliminary data showing the distinct advantages in various types of wounds. < p > Method: This case series involved the treatment of acute cases of wounds or chronic wounds that did not respond well to conventional wound healing treatments with VG111 in patients with different etiologies. Thirteen cases of patients that included patients with diabetes, pressure ulcers, burns, trauma, and others treated with VG111 showed rapid wound healing in all the cases, even obviating the need for a graft when complete skin regeneration occurred. < p > Result: This was illustrated by clearing of the wound infections, reduction/disappearance of the exudate, appearance of intense granulation, epithelialization, and anti-biofilm activity followed by complete wound closure. This VG111 precludes the need for systemic antimicrobial agents in localized infections and therefore, this single agent is an attempt to address the limitations and the drawbacks of the available products. < p > Conclusion: Despite patients belonging to the old age group and having comorbidities like diabetes, still VG111 showed effective rapid wound healing, and that too without any scar formation in hardto- heal, infected, and non-infected wounds. < /p > .