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Sagalla N, Alexopoulos AS, Gordon AM, Ear B, Nwankwo VC, Mystakelis HA, Blalock DV, Van Voorhees E, Grubber JM, Lee RH, Crowley M, Soliman D, Carlson SM, Kosinski A, Cantrell S, Goldstein KM, Williams JW, Gierisch JM. Screening for Male Osteoporosis: A Systematic Review. 2022 Apr 1.
Osteoporosis is a systemic skeletal disease characterized by low bone mass and deterioration of the fine structures of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Although studied mainly in postmenopausal women, osteoporosis has been recognized as a prevalent disease in men through similar mechanisms (, age-related bone loss, hormonal alterations, and other conditions/risk factors associated with bone loss). However, larger bone size, later onset of increased bone resorption, and lower fall risk are protective factors in men leading to a lower lifetime risk of fracture: 53.2% among women versus 20.7% among men. Despite a lower risk of fracture, for unclear reasons, men have higher rates of osteoporotic fracture-related complications and mortality than women.
