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PPO 21-067 – HSR Study

PPO 21-067
Client Language Analysis in Veterans and Non-Veterans with Low Motivation to Quit Smoking: Identifying Mechanisms of Change
Ellen Herbst, MD
San Francisco VA Medical Center, San Francisco, CA
San Francisco, CA
Funding Period: October 2021 - March 2024


Background: Veterans disproportionately suffer cigarette-related disease and death relative to the general population, but Veterans often endorse low motivation to quit. Analysis of client language with unmotivated smokers may provide new insights into how motivation shifts in response to different therapies. Therapies for unmotivated smokers include motivational interviewing (MI), which aims to enhance intrinsic motivation by resolving ambivalence; and health education (HE), which delivers scripted health advice. MI research suggests that increased in-session client “change talk” (CT), or language reflecting commitment to change the target behavior, relative to “sustain talk” (ST), or language reflecting plans to continue the target behavior, is associated with improved treatment outcomes. HE may contain client statements reflecting learning, or “learning talk” (LT), in response to health information, which may lead to improved outcomes through a different therapeutic mechanism. We propose to analyze client language from two randomized controlled trials (RCTs) comparing MI to HE with unmotivated smokers conducted by our Co-Investigators, including 1) a community RCT with 255 unmotivated smokers; and 2) a Veterans Health Administration (VHA) pilot study with 85 Veteran smokers with mental illness, of which a subset reported low motivation to quit. Analysis of client language in MI and HE sessions from these studies with unmotivated smokers will provide insight into the mechanisms underlying MI and HE. Significance/Impact: Given the high prevalence of smoking in Veterans, identifying therapeutic techniques associated with positive outcomes in unmotivated smokers has great potential to improve Veteran health. This project addresses HSR&D priorities of mental health, primary care practice, and quality/safety. Innovation: This mixed methods project is the first of its kind to examine aspects of in-session client language as predictors of treatment outcomes in unmotivated smokers, a population representative of most Veteran smokers in VHA care. Specific Aims: Aim 1 is to code client language in audio recorded MI and HE sessions from two RCTs with unmotivated smokers, including a community sample and a Veteran sample. We hypothesize that in both datasets, proportion of CT will be higher in MI than HE and that LT will be higher in HE than in MI. Aim 2 is to examine the relationship between proportion of CT to ST and proportion of LT to RT and 3- and 6- month treatment outcomes in the community sample. We hypothesize that that a higher proportion of CT relative to ST will be positively associated with treatment outcomes, both in MI and HE; that a higher proportion of LT relative to RT will be positively associated with outcomes, both in MI and HE; and that both high CT and high LT in the same session will be associated with improved outcomes relative to either high CT alone or ST alone irrespective of treatment group. We also hypothesize that proportion of CT will mediate treatment effects in MI, and proportion of LT will mediate treatment effects in HE. Aim 3 is to use results to develop a brief manual for Veteran smokers incorporating HE and MI. Methodology: We will use mixed methods to code and analyze 102 MI and 102 HE sessions from the community RCT and 15 MI and 15 HE sessions from the VHA RCT. To code sessions, we will use the Motivational Interviewing Skill Code 2.5 (MISC 2.5), a validated MI client language measure, to code CT and ST; and a LT coding extension system of the MISC 2.5 developed by our team to quantify client language LT, or reflective of client learning; and client rejection of health information, or rejection talk (RT). We will use findings to develop a brief manual for unmotivated Veteran smokers in VHA clinics. Throughout the project, we will work with an advisory panel of Veteran stakeholders and VHA leaders, who will provide input on the manual. Implementation/Next Steps: The ultimate goal of the project is to identify therapeutic mechanisms of action underlying MI and HE for unmotivated smokers. Findings will allow our team to apply for funding to test a brief intervention incorporating effective techniques from both HE and MI for unmotivated veteran smokers in VHA clinical settings.

External Links for this Project

NIH Reporter

Grant Number: I21HX003410-01

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None at this time.

DRA: Mental, Cognitive and Behavioral Disorders, Substance Use Disorders
DRE: TRL - Applied/Translational
Keywords: Outcomes - Patient, Substance Use and Abuse
MeSH Terms: None at this time.

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