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ATHENA-HF: Integrating Computable Guidelines for Complex Co-morbidities
Mary K. Goldstein, MD MS
VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, CA
Funding Period: August 2009 - July 2010
Healthcare providers face the challenge of growing complexity in medical science and technology, and are inundated with information about how to produce good outcomes in patient care. Clinical practice guidelines (CPGs) define evidence-based practices for heart failure management that reduce morbidity and mortality. Health technology in the VA is well-poised to support patient-specific evidence-based recommendations displayed at the point of clinical decision making. Such systems require a computable format of clinical knowledge.
The objective of this project was to build on previous work on the ATHENA-Clinical Decision Support (CDS) system to develop a prototype computable knowledge base (KB) of recommendations for managing heart failure (HF). The aims were to develop a guideline specification for computer representation of key steps in HF management; to encode the specification in a KB, ATHENA-HF; and to integrate other guideline KBs for commonly co-occurring conditions.
VA QUERI HF experts selected the ACC/AHA guidelines for HF as the CPG to encode. In collaboration with the VA Chronic Heart Failure (CHF) QUERI, knowledge engineers encoded the recommendations using the open-source knowledge acquisition system Protege with the EON model, a model designed to encode CPGs. Clinical concepts were extracted from each recommendation and represented as classes in Protege, and the source for patient data for them were identified. Subject matter experts clarified sections of the guideline that were ambiguous and added information necessary to make the recommendations actionable. Accuracy of encoding was evaluated using the testing environment in Protege. We explored methods to run other previously encoded ATHENA-KBs for patients with co-morbidity.
We encoded 53 recommendations for Stages A, B, and C of HF. Stage D (refractory HF) was defined as out of scope. These recommendations included 123 clinical concepts. The data required for the majority of concepts is available as structured data elements in the VistA electronic medical record (e.g., medications) while a few would require either natural language processing of free-text data (e.g., ejection fraction) or user input at the time of the patient visit (e.g., current symptoms). Preliminary testing with 28 test cases confirmed all recommendations were generated for appropriate cases. We successfully loaded and ran additional guidelines with ATHENA-HF providing recommendations across multiple conditions for patients with these comorbidities: diabetes (DM) glycemic control, foot care, and eye care; hypertension; hyperlipidemia; and chronic kidney disease. The system first evaluates patient's eligibility for each guideline and then generates recommendations for managing each condition.
The development of computable clinical best practices can potentially improve quality of care and outcomes for veterans, in this case Veterans with HF, by providing evidence-based patient specific recommendations at the time of clinical decision-making. This computable knowledge can be used in different settings such as primary care or heart failure teams as well as in quality improvement initiatives. Recommendations can be made for multiple diseases concurrently.
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Keywords: Clinical practice guidelines, Comorbidity, Decision support
MeSH Terms: none