The association between Self-Reported Medication Adherence scores and systolic blood pressure control: a SPRINT baseline data study.

Haley WE, Gilbert ON, Riley RF, Newman JC, Roumie CL, Whittle J, Kronish IM, Tamariz L, Wiggers A, Morisky DE, Conroy MB, Kovalik E, Kressin NR, Muntner P, Goff DC, SPRINT Study Research Group. The association between Self-Reported Medication Adherence scores and systolic blood pressure control: a SPRINT baseline data study. Journal of the American Society of Hypertension : JASH. 2016 Nov 1; 10(11):857-864.e2.

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Abstract:

We examined baseline data from the Systolic Blood Pressure Intervention Trial (SPRINT) to investigate whether medication adherence, measured by the 8-item Morisky Medication Adherence Scale (MMAS-8), was associated with systolic blood pressure (SBP) and whether MMAS-8 score and number of antihypertensive medications interacted in influencing SBP. A total of 8435 SPRINT participants were included: 21.2% had low adherence (MMAS-8: < 6); 40.0% had medium adherence (6 to < 8); and 38.8% had high adherence (8). SBP was < 140 mm Hg in 54.6%; 140-160 mm Hg in 36.6%; and > 160 mm Hg in 8.8%. In multivariable regression, medium vs. low adherence weakly associated with lower SBP (odds ratio: 1.17; confidence interval: 1.04, 1.31). SPRINT eligibility criteria should be considered when interpreting results. Efforts to understand and enhance adherence are crucial to improve population health, and using self-report instruments might be considered for predicting treatment adherence and response in future efficacy trials and for identifying patients for adherence support in clinical practice.