Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Health Services Research & Development

Go to the ORD website
Go to the QUERI website

HSR&D Citation Abstract

Search | Search by Center | Search by Source | Keywords in Title

Exclusion criteria in treatment research on alcohol, tobacco and illicit drug use disorders: A review and critical analysis.

Moberg CA, Humphreys K. Exclusion criteria in treatment research on alcohol, tobacco and illicit drug use disorders: A review and critical analysis. Drug and Alcohol Review. 2017 May 1; 36(3):378-388.

Dimensions for VA is a web-based tool available to VA staff that enables detailed searches of published research and research projects.

If you have VA-Intranet access, click here for more information vaww.hsrd.research.va.gov/dimensions/

VA staff not currently on the VA network can access Dimensions by registering for an account using their VA email address.
   Search Dimensions for VA for this citation
* Don't have VA-internal network access or a VA email address? Try searching the free-to-the-public version of Dimensions



Abstract:

ISSUES: High rates of exclusion in substance use disorder treatment studies reduce the external validity and clinical utility of research findings to an unknown extent. Accordingly, the current review examined commonly used exclusion criteria and their effect on study samples and outcomes. APPROACH: English-language literature was identified by PubMed searches and review of identified articles' reference lists. Studies were included if they analysed data on: (i) the prevalence and nature of exclusion criteria in the substance use disorder treatment field; and/or (ii) the impact of exclusion criteria on sample representativeness or study results. KEY FINDINGS: The search yielded 22 studies examining different aspects of exclusion criteria, including 15 empirical examinations of the impact of study exclusion criteria across different substance use disorder treatments on enrolment and outcome results. Aggregating across these 15 studies, we estimated that between 64 and 96% of potential study participants are excluded from substance use disorder treatment studies. IMPLICATIONS: The widespread exclusion of large proportions of people with substance use disorders limits the external validity of the substance use disorder treatment research literature. CONCLUSION: Although some eligibility criteria are necessary to protect participant safety and ensure internal validity, researchers conducting studies on substance use disorder treatments should thoughtfully consider the justification for and specific operationalisation of the extensive exclusion criteria they often utilise. [Moberg C, Humphreys K. Exclusion criteria in treatment research on alcohol, tobacco and illicit drug use disorders: A review and critical analysis. Drug Alcohol Rev 2017;36:378-388].





Questions about the HSR&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.