HSR&D Citation Abstract
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Characterizing weekly self-reported antihypertensive medication nonadherence across repeated occasions.
Voils CI, King HA, Neelon B, Hoyle RH, Reeve BB, Maciejewski ML, Yancy WS. Characterizing weekly self-reported antihypertensive medication nonadherence across repeated occasions. Patient preference and adherence. 2014 May 7; 8:643-50.
Little is known about weekly variability in medication nonadherence both between and within persons.
To characterize medication nonadherence across repeated, closely spaced occasions.
This prospective cohort study comprised four unannounced telephone assessment occasions, each separated by approximately 2 weeks. On each occasion, adult outpatients taking at least a single antihypertensive medication completed a measure of extent of, and reasons for, nonadherence.
Two hundred and sixty-one participants completed 871 (83%) of 1,044 occasions. Nonadherence was reported on 152 (17.5%) of 871 occasions by 93 (36%) of 261 participants. The most commonly endorsed reasons for nonadherence were forgetting (39.5%), being busy (23.7%), and traveling (19.7%). Among 219 participants completing at least three occasions, 50% of the variability in extent of nonadherence was a result of within-person fluctuations, and 50% was a result of between-person differences.
Interventions to reduce nonadherence should be informed by variability in the extent of nonadherence and specific reasons for nonadherence.