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Examining the relationship between fluoroquinolone use and Clostridium difficile infections (CDI): A meta-analysis

Formanek BS, Herwaldt L, McDanel J, Blevins A, Schweizer ML. Examining the relationship between fluoroquinolone use and Clostridium difficile infections (CDI): A meta-analysis. Poster session presented at: Infectious Diseases Society of America Annual Meeting; 2013 Oct 4; San Francisco, CA.


Background: The incidence of CDI has increased substantially during the past decade. C. difficile is now one of the most important causes of healthcare-associated infections. Antimicrobial use is the primary risk factor for CDI. Several small studies have assessed whether fluoroquinolones increase the risk of CDI more than other antimicrobials. Methods: We performed systematic literature searches in PubMed, Wiley's Cochrane Database of Systematic Reviews (CDSR), Wiley's Database of Abstracts of Reviews of Effects (DARE), Wiley's Cochrane Central Register of Controlled Trials (CENTRAL), Scopus (including EMBASE abstracts), and We ran the searches on October 15, 2012 with no limits on date or language. We used a random-effects model to obtain meta-analysis summary estimates. After reviewing 431 article abstracts and reviewing 22 articles in detail, we pooled risk estimates from 17 independent study populations. Results: When we pooled the crude data from all 17 studies in a random-effects model, fluoroquinolone use was significantly associated with a higher risk of CDI than other antimicrobials (pooled OR: 2.93; 95% CI: 2.12, 4.05). Twelve of 17 studies provided adjusted risk estimates. When we pooled the adjusted data, fluoroquinolone use remained a significant risk factor for CDI, albeit with a lower pooled OR (pooled OR: 1.71; 95% CI: 1.48, 1.96). Conclusion: Fluoroquinolone use was associated with increased risk of CDI compared with other antimicrobials. Antibiotic stewardship campaigns to limit to use of fluoroquinolones may decrease the incidence of healthcare-associated CDI

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