Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Health Services Research & Development

Go to the ORD website
Go to the QUERI website

HSR&D Citation Abstract

Search | Search by Center | Search by Source | Keywords in Title

Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury.

Carbone LD, Chin AS, Lee TA, Burns SP, Svircev JN, Hoenig HM, Bailey L, Weaver FM. Thiazide use is associated with reduced risk for incident lower extremity fractures in men with spinal cord injury. Archives of physical medicine and rehabilitation. 2014 Jun 1; 95(6):1015-20.

Dimensions for VA is a web-based tool available to VA staff that enables detailed searches of published research and research projects.

If you have VA-Intranet access, click here for more information vaww.hsrd.research.va.gov/dimensions/

VA staff not currently on the VA network can access Dimensions by registering for an account using their VA email address.
   Search Dimensions for VA for this citation
* Don't have VA-internal network access or a VA email address? Try searching the free-to-the-public version of Dimensions



Abstract:

OBJECTIVE: To determine the association between thiazide use and lower extremity fractures in patients who are men with a spinal cord injury (SCI). DESIGN: Cohort study from fiscal years 2002 to 2007. SETTING: Medical centers. PARTICIPANTS: Men (N = 6969) with an SCI from the Veterans Affairs (VA) Spinal Cord Dysfunction (SCD) Registry, including 1433 users of thiazides and 5536 nonusers of thiazides. INTERVENTION: Thiazide use versus nonuse. MAIN OUTCOME MEASURE: Incident lower extremity fractures. RESULTS: Among the men, 21% in the VA SCD Registry (fiscal years 2002-2007) included in these analyses used thiazide diuretics. There were 832 incident lower extremity fractures over the time period of this study: 110 fractures (7.7%) in 1433 thiazide users and 722 fractures (13%) in 5536 nonusers of thiazides. In unadjusted and adjusted models alike, thiazide use was associated with at least a one-quarter risk reduction in lower extremity fracture at any given point in time (unadjusted: hazard ratio (HR) = .75; 95% confidence interval (CI), .59-.94; adjusted: HR = .74; 95% CI, .58-.95). CONCLUSIONS: Thiazide use is common in men with SCI and is associated with a decreased likelihood for lower extremity fractures.





Questions about the HSR&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.