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Predictors of Health-related Quality of Life in HIV Patients with Depression

Pyne JM, Triapthi S. Predictors of Health-related Quality of Life in HIV Patients with Depression. Paper presented at: International Society for Quality of Life Research Annual Meeting; 2009 Jul 20; Italy.


Predictors of Health-related Quality of Life in HIV Patients with Depression Objective: Previous studies consistently identify depression as an important predictor of health-related quality of life (HRQL) in HIV patients. To our knowledge there are no papers comparing the sensitivity or predictors of HRQL in HIV patients using different HRQL measures. In this paper we compare the sensitivity and predictors of two generic HRQL measures in a sample of depressed HIV patients. Methods: 249 subjects completed baseline assessments as part of an ongoing study to test a collaborative care intervention to improve depression care in HIV patients. The HRQL measures included: self-administered Quality of Well-Being scale (QWB-SA) and the standard gamble weighted version of the SF-12 (SF-12 SG). Step-wise regression methods were used to determine significant predictors. Results: Significant QWB-SA predictors (decreasing t-value order) included: depression severity, HIV symptom count, current panic disorder, number chronic physical illnesses, and income (F = 25.95, p < 0.001, adjusted R-squared = 0.39). Significant SF-12 SG predictors included: depression severity, number chronic physical illnesses, and HIV symptom count (F = 51.19, p < 0.001, adjusted R-square = 0.38). Conclusions: The variance explained by each HRQL is similar. The QWB-SA includes a wider range of significant predictors. The choice of which measure to use can be made on the basis of time to complete (favoring SF-12) or interventions that target a wider range of predictors (favoring QWB-SA).

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