Beyond Guideline-Directed Medical Therapy: Nonpharmacologic Management for Patients With Heart Failure.

Ilonze OJ, Forman DE, LeMond L, Myers J, Hummel S, Vest AR, DeFilippis EM, Habib E, Goodlin SJ. Beyond Guideline-Directed Medical Therapy: Nonpharmacologic Management for Patients With Heart Failure. JACC. Heart failure. 2025 Feb 1; 13(2):185-199, DOI: 10.1016/j.jchf.2024.08.018.

Heart failure (HF) is a leading cause of cardiovascular morbidity, mortality, and health care expenditure. Guideline-directed medical therapy and device-based therapy in HF are well established. However, the role of nonpharmacologic modalities to improve HF care remains underappreciated, is underused, and requires multimodal approaches to care. Diet, exercise and cardiac rehabilitation, sleep-disordered breathing, mood disorders, and substance use disorders are potential targets to reduce morbidity and improve function of patients with HF. Addressing these factors may improve symptoms and quality of life, reduce hospitalizations, and improve mortality in heart failure. This state-of-the-art review discusses dietary interventions, exercise programs, and the management of sleep-disordered breathing, mood disorders, and substance use in individuals with heart failure. The authors review the latest data and provide optimal lifestyle recommendations and recommended prescriptions for nonpharmacologic therapies.