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Preparing for pragmatic trials in dementia care: Health equity considerations for nonpharmacological interventions.

Aranda MP, Baier R, Hinton L, Peak KD, Jackson JD, Dilworth-Anderson P, Gitlin LN, Jutkowitz E, QuiƱones AR. Preparing for pragmatic trials in dementia care: Health equity considerations for nonpharmacological interventions. Journal of the American Geriatrics Society. 2023 Sep 1.

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Inequities with regard to brain health, economic costs, and the evidence base for dementia care continue. Achieving health equity in dementia care requires rigorous efforts that ensure disproportionately affected populations participate fully in-and benefit from-clinical research. Embedding-proven interventions under real-world conditions and within existing healthcare systems have the potential to examine the effectiveness of an intervention, improve dementia care, and leverage the use of existing resources. Developing embedded pragmatic controlled trials (ePCT) research designs for nonpharmacological dementia care interventions involves a plethora of a priori assumptions and decisions. Although frameworks exist to determine whether interventions are "ready" for ePCT, there is no heuristic to assess health equity-readiness. We discuss health equity considerations, case examples, and research strategies across ePCT study domains of evidence, risk, and alignment. Future discussions regarding health equity considerations across other domains are needed.

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