The association between daily sedentary and active bout frequency with mortality risk in older men using accelerometry.

Roe LS, Harrison S, Cawthon PM, Moored KD, Qiao YS, Ensrud K, Stone KL, Gabriel KP, Cauley JA, Osteoporotic Fractures in Men (MrOS) Study Research Group. The association between daily sedentary and active bout frequency with mortality risk in older men using accelerometry. Journal of the American Geriatrics Society. 2023 May 1; 71(5):1547-1557.

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Abstract:

BACKGROUND: Time awake with advancing age is increasingly spent sedentary and has several negative health consequences. We examined associations between the frequency of daily sedentary and active bouts with all-cause mortality. METHODS: Data are from 2816 men in the Osteoporotic Fractures in Men (MrOS) Study (mean age?±?SD: 79.1?±?5.2?years) with free-living activity monitor (SenseWear® Pro3 Armband) data (5.1?±?0.3?days worn > 90%) at the Year 7 visit (2007-2009). Sedentary bout frequency was defined as the number of sedentary bouts per day lasting 5+ min to activity of any intensity. Active bout frequency was defined as the number of active bouts per day lasting 5+ min to sedentary behavior. Sleep time was excluded from the analysis. Deaths were centrally adjudicated using death certificates. Cox proportional hazard models were used to separately examine associations between quartiles of sedentary (Q1 referent, < 13.6 bouts/day) or active (Q1 referent, < 5 bouts/day) bout frequency with mortality. RESULTS: After 9.3?±?3.8?years of follow-up, 1487 (52.8%) men died. Men averaged 16.8?±?5.1 and 8.2?±?4.2 sedentary and active bouts/day, respectively. After full covariate adjustment, each quartile reflecting more frequent sedentary bouts (Q4 vs. Q1 HR: 0.69, 95%CI: 0.58, 0.81, p-trend < 0.001) was associated with lower mortality risk. Likewise, each quartile reflecting more frequent active bouts (Q4 vs. Q1 HR: 0.58, 95%CI: 0.49, 0.70, p-trend < 0.001) was associated with lower mortality risk. Results for the sedentary bouts model remained significant after adjusting for total minutes per day in sedentary behavior (Q4 vs. Q1 HR: 0.63, 95%CI: 0.61, 0.86, p-trend  =  0.001). The association between active bout frequency with mortality was attenuated after adjusting for total minutes per day active. CONCLUSIONS: Regardless of total time spent sedentary, reducing duration of sedentary bouts with more frequent and shorter bouts may be a simple and feasible method to delay mortality risk among community-dwelling older men.