Secondary Prevention Risk Interventions via Telemedicine and Tailored Patient Education (SPRITE): A randomized trial to improve post myocardial infarction management.

Zullig LL, Peterson ED, Shah BR, Grambow SC, Oddone EZ, McCant F, Lindquist JH, Bosworth HB. Secondary Prevention Risk Interventions via Telemedicine and Tailored Patient Education (SPRITE): A randomized trial to improve post myocardial infarction management. Patient education and counseling. 2022 Sep 1; 105(9):2962-2968.

Related HSR&D Project(s)

• RCS 08-027 – Research Career Scientist Award

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Abstract:

OBJECTIVE: We evaluated the impact of a low intensity web-based and intensive nurse-administered intervention to reduce systolic blood pressure (SBP) among patients with prior MI. METHODS: Secondary Prevention Risk Interventions via Telemedicine and Tailored Patient Education (SPRITE) was a three-arm trial. Patients were randomized to 1) post-MI education-only; 2) nurse-administered telephone program; or 3) web-based interactive tool. The study was conducted 2009-2013. RESULTS: Participants (n  =  415) had a mean age of 61 years (standard deviation [SD], 11). Relative to the education-only group, the 12-month differential improvement in SBP was - 3.97 and - 3.27 mmHg for nurse-administered telephone and web-based groups, respectively. Neither were statistically significant. Post hoc exploratory subgroup analyses found participants who received a higher dose ( > 12 encounters) in the nurse-administered telephone intervention (n  =  60; 46%) had an 8.8 mmHg (95% CI, 0.69, 16.89; p  =  0.03) differential SBP improvement versus low dose ( < 11 encounters; n  =  71; 54%). For the web-based intervention, those who had higher dose (n  =  73; 53%; > 1 web encounter) experienced a 2.3 mmHg (95% CI, -10.74, 6.14; p  =  0.59) differential SBP improvement versus low dose (n  =  65; 47%). CONCLUSIONS: The main effects were not statistically significant. PRACTICAL IMPLICATIONS: Completing the full dose of the intervention may be essential to experience the intervention effect. CLINICAL TRIAL REGISTRATION: The unique identifier is NCT00901277 (http://www. CLINICALTRIALS: gov/ct2/show/NCT00901277?term = NCT00901277andrank = 1).