Can we clinically identify pre-symptomatic and asymptomatic COVID-19?

Elhamamsy S, DeVone F, Bayer T, Halladay C, Cadieux M, McConeghy K, Rajan A, Sachar M, Mujahid N, Nanda A, McNicoll L, Rudolph JL, Gravenstein S. Can we clinically identify pre-symptomatic and asymptomatic COVID-19? medRxiv : the preprint server for health sciences [Preprint]. 2021 Jul 26.

Objectives: COVID-19 has had a severe impact on morbidity and mortality among nursing home (NH) residents. Earlier detection of SARS-CoV-2 may position us to better mitigate risk of spread. Both asymptomatic or pre-symptomatic transmission are common in outbreaks, and threshold temperatures, such as 38C, for screening for infection could miss timely detection in the majority. Design: Retrospective cohort study using electronic health records. Methods: We hypothesized that in long-term care residents, temperature trends with SARS-CoV-2 infection could identify infection in pre-symptomatic and asymptomatic individuals earlier. We collected information about age and other demographics, baseline temperature, and specific comorbidities. We created standardized definitions, and an alternative hypothetical model to test measures of temperature variation and compare outcomes to the VA reality. Settings and participants: Our subjects were 6,176 residents of the VA NHs who underwent SARS-CoV-2 trigger testing. Results: We showed that a change from baseline of > 0.4C identifies 47% of the SARS-CoV-2 positive NH residents early, and achieves earlier detection by 42.2 hours. Range improves early detection to 55% when paired with a 37.2C cutoff, and achieves earlier detection by 44.4 hours. Temperature elevation > 0.4C from baseline, when combined with a 0.7C range, would detect 52% early, leading to earlier detection by more than 3 days in 22% of the residents. This earlier detection comes at the expense of triggering 57,793 tests, as compared to the number of trigger tests ordered in the VA system of 40,691. Conclusion and implications: Our model suggests that current clinical screening for SARS-CoV-2 in NHs can be substantially improved upon by triggering testing using a patient-derived baseline temperature with a 0.4C degree relative elevation or temperature variability of 0.7C trigger threshold for SARS-CoV2 testing. Such triggers could be automated in facilities that track temperatures in their electronic records.