HSR&D Citation Abstract
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Factors associated with non-adherence to insulin and non-insulin medications in patients with poorly controlled diabetes.
Sagalla N, Yancy WS, Edelman D, Jeffreys AS, Coffman CJ, Voils CI, Alexopoulos AS, Maciejewski ML, Dar M, Crowley MJ. Factors associated with non-adherence to insulin and non-insulin medications in patients with poorly controlled diabetes. Chronic Illness. 2022 Jun 1; 18(2):398-409.
To evaluate differences in factors associated with self-reported medication non-adherence to insulin and non-insulin medications in patients with uncontrolled type 2 diabetes.
In this secondary analysis of a randomized trial in patients with obesity and uncontrolled type 2 diabetes, multivariable logistic regression was used to evaluate associations between several clinical factors (measured with survey questionnaires at study baseline) and self-reported non-adherence to insulin and non-insulin medications.
Among 263 patients, reported non-adherence was 62% (52% for insulin, 55% for non-insulin medications). Reported non-adherence to non-insulin medications was less likely in white versus non-white patients (odds ratio (OR)? = 0.42; 95%CI: 0.22,0.80) and with each additional medication taken (OR? = 0.75; 95%CI: 0.61,0.93). Non-adherence to non-insulin medications was more likely with each point increase in a measure of diabetes medication intensity (OR? = 1.43; 95%CI: 1.01,2.03), the Problem Areas in Diabetes (PAID) score (OR? = 1.06; 95%CI: 1.02,1.12), and in men versus women (OR? = 3.03; 95%CI: 1.06,8.65). For insulin, reporting non-adherence was more likely (OR? = 1.02; 95%CI: 1.00,1.04) with each point increase in the PAID.
Despite similar overall rates of reported non-adherence to insulin and non-insulin medications, factors associated with reported non-adherence to each medication type differed. These findings may help tailor approaches to supporting adherence in patients using different types of diabetes medications.