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Attia EF, Jacobson D, Yu W, Crowell CS, Maleche-Obimbo E, Williams PL, West TE, Burchett SK, Kattan M, Colin AA, Eskander S, Chung MH, Crothers K, Shearer WT, Pediatric HIV/AIDS Cohort Study. Immune imbalance and activation are associated with lower lung function in youth with perinatally acquired HIV. The Journal of allergy and clinical immunology. 2020 May 1; 145(5):1473-1476.
High CD8 T-cells and low CD4/CD8 are associated with lower lung function among youth living with perinatally-acquired HIV, despite antiretroviral therapy and CD4 preservation/reconstitution. Understanding these underlying mechanisms is critical to mitigate lung function impairment.