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Franco FGM, Laurinavicius AG, Lotufo PA, Conceição RD, Morita F, Katz M, Wajngarten M, Carvalho JAM, Bosworth HB, Santos RD. Persistent Depressive Symptoms are Independent Predictors of Low-Grade Inflammation Onset Among Healthy Individuals. Arquivos brasileiros de cardiologia. 2017 Jun 29; 109(2):97-102,180.
Dimensions for VA is a web-based tool available to VA staff that enables detailed searches of published research and research projects. Background:: Depressive symptoms are independently associated with an increased risk of cardiovascular disease (CVD) among individuals with non-diagnosed CVD. The mechanisms underlying this association, however, remain unclear. Inflammation has been indicated as a possible mechanistic link between depression and CVD. Objectives:: This study evaluated the association between persistent depressive symptoms and the onset of low-grade inflammation. Methods:: From a database of 1,508 young (mean age: 41 years) individuals with no CVD diagnosis who underwent at least two routine health evaluations, 134 had persistent depressive symptoms (Beck Depression Inventory - BDI 10, BDI+) and 1,374 had negative symptoms at both time points (BDI-). All participants had been submitted to repeated clinical and laboratory evaluations at a regular follow-up with an average of 26 months from baseline. Low-grade inflammation was defined as plasma high-sensitivity C-Reactive Protein (CRP) concentrations > 3 mg/L. The outcome was the incidence of low-grade inflammation evaluated by the time of the second clinical evaluation. Results:: The incidence of low-grade inflammation was more frequently observed in the BDI+ group compared to the BDI- group (20.9% vs. 11.4%; p = 0.001). After adjusting for sex, age, waist circumference, body mass index, levels of physical activity, smoking, and prevalence of metabolic syndrome, persistent depressive symptoms remained an independent predictor of low-grade inflammation onset (OR = 1.76; 95% CI: 1.03-3.02; p = 0.04). Conclusions:: Persistent depressive symptoms were independently associated with low-grade inflammation onset among healthy individuals. Fundamento:: Sintomas depressivos est o associados de forma independente ao risco aumentado de doen a cardiovascular (DCV) em indiv duos com DCV n o diagnosticada. Os mecanismos subjacentes a essa associa o, entretanto, n o est o claros. Inflama o tem sido indicada como um poss vel elo mecanicista entre depress o e DCV. Objetivos:: Este estudo avaliou a associa o entre sintomas depressivos persistentes e o in cio de inflama o de baixo grau. M todos:: De um banco de dados de 1.508 indiv duos jovens (idade m dia: 41 anos) sem diagn stico de DCV submetidos a pelo menos duas avalia es de sa de de rotina, 134 tinham sintomas depressivos persistentes (Invent rio de Depress o de Beck - BDI 10, BDI+) e 1.374 n o apresentavam sintomas em nenhuma das ocasi es (BDI-). Todos os participantes foram submetidos a repetidas avalia es cl nicas e laboratoriais em seguimento regular, cuja m dia foi de 26 meses desde a condi o basal. Definiu-se inflama o de baixo grau como concentra o plasm tica de prote na C reativa (PCR) ultrassens vel > 3 mg/L. O desfecho foi a incid ncia de inflama o de baixo grau por ocasi o da segunda avalia o cl nica. Resultados:: A incid ncia de inflama o de baixo grau foi maior no grupo BDI+ em compara o ao grupo BDI- (20,9% vs. 11,4%; p = 0,001). Ap s ajuste para sexo, idade, circunfer ncia abdominal, ndice de massa corporal, n veis de atividade f sica, tabagismo e preval ncia de s ndrome metab lica, os sintomas depressivos persistentes continuaram sendo um preditor independente de in cio de inflama o de baixo grau (OR = 1,76; IC 95%: 1,03-3,02; p = 0,04). Conclus es:: Sintomas depressivos persistentes foram independentemente associados com in cio de inflama o de baixo grau em indiv duos saud veis.
