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|Issue 120||December 2016|
The report is a product of the VA/HSR&D Evidence Synthesis Program.
The Effectiveness and Risks of Cranial Electrical Stimulation: A Systematic Review
Cranial electrical stimulation (CES) is a non-invasive method of applying low-intensity electrical current to the head. It is related to but distinct from other forms of transcranial electrical stimulation (i.e., electroconvulsive therapy and transcranial direct current stimulation), with different versions of stimulation varying in the placement of electrodes, intensity of the current, and waveform of the current. After an initial burst of research activity in the 1970s and early 1980s, published research on CES slowed, but then accelerated beginning in 2005. One driver for the resurgence in interest in CES has been VA and Department of Defense practitioners that prescribe CES for anxiety, PTSD, insomnia, depression, and headache.
Investigators with VA’s Evidence-based Synthesis Program Center located in West Los Angeles, California searched multiple databases from inception to October 10, 2017 for evidence about the effectiveness and harms of CES for patients with chronic painful conditions, depression, anxiety, PTSD, and insomnia. From 1,924 potentially relevant citations, 28 publications from 26 randomized controlled trials (RCTs) met eligibility criteria for this systematic review and were used to address the following key questions:
Summary of Review
The principal conclusions of this systematic review are that the evidence is insufficient to support conclusions that CES has clinically important effects on headache, fibromyalgia, neuromuscular pain, depression, PTSD, or insomnia. There is low-strength evidence for a possible beneficial effect of modest size in patients who have anxiety with depression. CES is probably safe, in that no serious side effects have been reported, although reporting bias is present.
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ESP is currently soliciting review topics from the broader VA community. Nominations will be accepted electronically using the online Topic Submission Form. If your topic is selected for a synthesis, you will be contacted by an ESP Center to refine the questions and determine a timeline for the report.
This Management e-Brief is provided to inform you about recent HSR&D findings that may be of interest. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs. If you have any questions or comments about this Brief, please email CIDER. The Center for Information Dissemination and Education Resources (CIDER) is a VA HSR&D Resource Center charged with disseminating important HSR&D findings and information to policy makers, managers, clinicians, and researchers working to improve the health and care of Veterans.
This report is a product of VA/HSR&D's Quality Enhancement Research Initiative's (QUERI) Evidence-Based Synthesis Program (ESP), which was established to provide timely and accurate synthesis of targeted healthcare topics of particular importance to VA managers and policymakers – and to disseminate these reports throughout VA.
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