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Mild TBI Diagnosis and Management Strategies

Recent Advances in Neuroimaging of Veterans with Mild traumatic Brain Injury, Sub-concussive Exposure, and Posttraumatic Stress Disorder


by Rajendra Morey, MD, MS ; David Salat, PhD
Seminar date: 4/26/2022

Description: Presentation 1: Advances in data driven methods for investigating white matter structure and functional connections in mild TBI and subconcussive blast exposure

Blast concussion in military veterans affects white matter structure in a heterogenous manner both spatially and in terms of magnitude of white matter injury. These difference may be attributed to specific events surrounding blast exposure such as direction of blast, reflective surfaces, head and body protection, distance from blast, and intensity of blast among others. We explore methods for defining regions of interest for investigating white matter in mild TBI and the results of data driven methods 1,000+ Veterans. Furthermore, asymptomatic exposure to blast does not preclude neurobiological insult. Effects of asymptomatic blast exposure on functional connections in canonical brain networks will be also reported.

Presentation 2: Recent advances in neuroimaging of Veterans with mild traumatic brain injury and post-traumatic stress disorder

Military service and combat exposure is associated with a range of factors that confer vulnerability to cognitive, behavioral, neurologic, and psychiatric symptoms in recent era Service Members. Brain imaging technologies provide an opportunity to understand causes of impairment and guide development of new therapies. We will review recent neuroimaging research findings in Veterans including findings from the TRACTS TBI National Research Center and NeRVe Center at VA Boston and discuss the challenges in linking brain measures to symptom expression in this complex population.

Intended Audience:
This seminar is intended for research investigators and clinicians interested in the use of neuroimaging methods to understand commonly occurring conditions in recent era Veterans.

View archived session video:



DOWNLOAD: PDF handout | Audio only (mp3) | transcript not yet available


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