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Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study.
Royse KE, El-Serag HB, Chen L, White DL, Hale L, Sangi-Haghpeykar H, Jiao L. Sleep Duration and Risk of Liver Cancer in Postmenopausal Women: The Women's Health Initiative Study. Journal of women's health (2002). 2017 Dec 1; 26(12):1270-1277.
Sleep duration has been associated with nonalcoholic fatty liver disease, but its association with liver cancer remains unknown.
MATERIAL AND METHODS:
In the prospective Women's Health Initiative Study, 139,368 postmenopausal women reported sleep habits at baseline (1993-1998). We ascertained 175 incident liver cancer cases during an average 13.8 years of follow-up through August 2014. We used multivariable Cox proportional hazard regression models to estimate a hazard ratio (HR) and its 95% confidence interval (95% CI) for risk of liver cancer in association with nocturnal sleep duration.
Compared to women reporting 6-8 hours of sleep, the HR for liver cancer was 1.94 (95% CI 1.07-3.53) for women reporting = 9 hours of sleep. Among the obese women, the HR associated with = 9 hours of sleep was 3.18 (95% CI 1.84-8.60). The HR was 0.93 (95% CI 0.34-2.53) among nonobese women (p value for interaction? = 0.18). Short sleep duration ( = 5 hours) was not associated with liver cancer risk.
Long sleep duration was associated with a moderate increase in liver cancer risk in obese postmenopausal women in the United States. Larger study is needed to confirm our observation on effect modification by adiposity status.